Does ovarian stimulation benefit ovulatory women undergoing therapeutic donor insemination?

ObjectiveTo compare clinical and ongoing pregnancy after natural cycle (NC) intrauterine insemination (IUI) versus ovarian stimulation (OS) IUI in ovulatory women undergoing therapeutic donor (TDI).DesignRetrospective cohort.SettingSingle infertility center.Patient(s)A total of 76,643 cycles patients treated with were examined. Women TDI the absence diagnosed female factor included.Intervention(s)NC or OS either clomiphene citrate letrozole.Main Outcome Measure(s)Clinical pregnancies analyzed by generalized estimating equations adjusting for age, body mass index, motile sperm at time number. Ongoing multiple gestations examined as a secondary outcome.Result(s)Six thousand one hundred ninety-two from 2,343 (711 without repeated cycles) met inclusion criteria available analysis (3,837 NC 2,355 OS). There was no difference mean age between two groups (NC, 34.2 years vs. OS, 34.3 years). Probability higher cohort compared (OS, 22.4% NC, 18.7% 15.4% 14.9%, respectively). However, significantly increased 10.8% 2.4%).Conclusion(s)Ovarian resulted <4% increase <1% pregnancy, more than fourfold gestations. Natural should be considered first-line treatment who need insemination. To (TDI). Retrospective cohort. Single center. A included. letrozole. Clinical outcome. Six 2.4%). Ovarian